Table 1.
Comparison of An. gambiae s.s. survival post feeding on different IVM concentrations spiked in glucose solution (A) or blood (B)
| A. Ivermectin bio-efficacy in 10% glucose solution | |||||
|---|---|---|---|---|---|
| Treatment | N | n | HR | 95% CI | p-value |
| IVM 85 ng/ml | 3 | 155 | 2.46 | 1.86–3.31 | < 0.001 |
| IVM 64 ng/ml | 3 | 150 | 1.68 | 1.24–2.26 | < 0.001 |
| IVM 43 ng/ml | 3 | 151 | 1.35 | 1.00–1.82 | 0.054 |
| IVM 21 ng/ml | 3 | 150 | 1.26 | 0.93–1.70 | 0.140 |
| No IVM—Control | 3 | 147 | 1 | – | – |
| B. Ivermectin bio-efficacy in blood | |||||
|---|---|---|---|---|---|
| Treatment | N | n | HR | 95% CI | p-value |
| IVM 85 ng/ml | 3 | 134 | 28.02 | 17.19–45.65 | < 0.001 |
| IVM 64 ng/ml | 3 | 132 | 24.27 | 14.89–39.56 | < 0.001 |
| IVM 43 ng/ml | 3 | 133 | 22.98 | 14.09–37.48 | < 0.001 |
| IVM 21 ng/ml | 3 | 139 | 7.77 | 4.73–12.75 | < 0.001 |
| No IVM—Control | 3 | 144 | 1 | – | – |
N number of replicates, n total number of mosquitoes, HR hazard ratios, CI confidence intervals
Log rank test comparing survival of An. gambiae s.s. mosquitoes after feeding on different IVM concentrations spiked in glucose solution (A) or blood (B)