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. 2023 Sep 29;23:922. doi: 10.1186/s12885-023-11447-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Stemness and EMT-like phenotypes of trastuzumab-resistant gastric cancer. (a) NCI-N87R cells had significantly larger sphere size and comprised higher cell counts of spheres larger than 50 μm compared with NCI-N87 cells. (b) E-cadherin was significantly downregulated in NCI-N87R cells, as confirmed by immunofluorescence, compared with parental cells. Stem cell markers including CD44s, CD54, BMI1, Oct4, Vimentin and Snail were significantly upregulated in NCI-N87R cells compared with parental cells, according to Western blot analysis. *P < 0.05, **P < 0.01, ***P < 0.005