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. 2023 Aug 9;483(3):393–404. doi: 10.1007/s00428-023-03612-8

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Fig. 1 — Examples of relevant histologic parameters and their levels. a Lack of tumour budding (HE, 100×). b Intermediate level of tumour budding (buds – arrows, HE, 400×). c High level of tumour budding (buds – arrows, HE, 400×). d Squamous cell carcinoma with small nuclear diameter (≤ 4 lymphocytes – arrow, HE, 400×). e Squamous cell carcinoma with large nuclear diameter (> 4 lymphocytes – arrow, HE, 400×). f Spread through air paces (STAS) in a case of squamous cell carcinoma (STAS – arrows, HE, 100×)