Table 3.

Linear mixed model results assessing the relationship between each ATN profile at baseline and at follow-up with cognitive decline measured through MMSE scores standardised to the A-T-N- profile. The model was fitted with random intercepts and slopes. p-values are the result of the interaction between profiles and time points. The β estimate at baseline represent the adjusted regression coefficient showing the association between groups and baseline MMSE results with the normal group as the reference. The β estimate at follow-up shows the adjusted regression coefficient showing the association between ATN group with annual decline in MMSE score, in comparison to the normal group as the reference

ATN Groups	Baseline			Follow-up
	β	Confidence Interval	p-value	β	Confidence Interval	p-value
AD-PC	− 0.82	− 3.28–1.65	0.52	− 1.13	− 3.21–0.95	0.29
AD-P	− 3.81	− 5.94–-1.68	< 0.01	− 3.21	− 5.01– − 1.42	< 0.01
SNAP	− 3.29	− 7.14–0.57	0.09	− 2.29	− 5.54–0.97	0.17

Abbreviations: A, amyloid; T, tau; N, neurodegeneration; AD, Alzheimer’s disease; AD-PC, AD pathological change; AD-P, AD pathology; β baseline, adjusted regression coefficient showing the association between profile classification and baseline MMSE result with the normal group as the reference; β follow-up, regression coefficient showing the association between ATN group with annual decline in MMSE score in comparison to the normal group as the reference