Table 1.
Description of the cohorts included in this retrospective analysis
| Cohort | Clinical data source | Clinical diagnosis | Objective for retrospective analysis | Subset analysis | Visual assessment |
|---|---|---|---|---|---|
| #1, n = 91 | NCT01020838 [8, 9] |
59 AD 4 DLB 9 DEM 19 NDV |
To assess the sensitivity and specificity of quantification methods against the histopathological confirmation | 3 expert blinded readers | |
| To compare the diagnostic performance of quantification methods with previously established visual assessment performed by 3 expert blinded readers and 5 newly trained blinded readers | 5 newly trained blinded readers | ||||
| #2, n = 439 | Images from clinical phase 1, 2, and 3 studies were visually assessed by five independent blinded readers in a pooled read study |
183 eHC 169 AD 9 DLB 11 FTLD 1 FTD 51 MCI 5 PD 4 VaD 6 other |
To assess the concordance between visual assessment performed by 5 blinded readers and binary quantitative assessment of FBB PET scans To assess agreement and reliability between (inter-software) and within (intra-software) analytical methods |
Subset 1 (n = 386): excluded subjects from cohort #1 used to generate the cut-off Subset 2 (n = 439): represents the full sample Subset 3 (n = 336): based on subset 2 and included only subjects with consensus among 5 independent blinded readers Subset 4 (n = 84): randomly selected scans to assess intra-software reliability |
5 newly trained blinded readers |
| #3, n = 45 | NCT01138111 [28] | 45 MCI |
To assess the prognostic accuracy of quantitative assessment of amyloid-beta load using FBB PET for progression to AD To assess the capacity of quantitative assessment of amyloid-beta load using FBB PET to detect longitudinal changes |
||
| #4, n = 35 | Global Alzheimer’s Association Information Network (GAAIN) [29] |
10 yHC 6 eHC 9 MCI 8 AD 2 FTD |
To compare the results of FBB PET quantification against the quantitative results provided in a publicly available dataset |
AD Alzheimer’s disease, DEM other dementia, DLB dementia with Lewy bodies, eHC elderly healthy control, FTD frontotemporal dementia, FTLD frontotemporal lobar degeneration, MCI amnestic mild cognitively impaired, NDV non-demented volunteer, PD Parkinson’s disease, VaD vascular dementia, yHC young healthy control