Table 2.

Summary of analytical methods included in the retrospective analysis

Analytical method id	Software	MRI required	Reference region	Metric	CE-marked	510(k)	References
#1	MIMneuro (v.7.1.2)	No	WC	CL	Yes	Yes	[30]
#2	Hermes BRASS (v.5.1.1)	No	WC	SUVR	Yes	Yes
#3	Neurocloud (v.1.4)	No	WC	SUVR	Yes	No
#4	Standard centiloid	Yes	WC	CL	No	No	[29, 31]
#5	Neurology Toolkit	No	WC	CL	No	No	[32]
#6	Neurology Toolkit	No	NA	Amyloid index	No	No	[32]
#7	SPM8	Yes	WC	SUVR	No	No
#8	SPM8	Yes	WC*	SUVR	No	No
#9	SPM8	Yes	CGM	SUVR	No	No
#10	SPM8	No	WC	CL	No	No
#11	PMOD Neuro (v.3.7)	Yes	CGM	SUVR	No	No
#12	CapAIBL	No	WC	CL	No	No	[33–35]
#13	NMF CapAIBL	No	WC	CL	No	No	[36]
#14	AmyloidIQ	Yes	NA	Amyloid load	No	Submitted1	[37, 38]
#15	AmyloidIQ	No	NA	Amyloid load	No	Submitted1	[37, 38]

CGM cerebellar gray matter, CL centiloid, NA not applicable, NMF non-negative matrix factorisation, SPM statistical parametric mapping, SUVR standardized uptake value ratio, WC whole cerebellum (volume weighted average of CGM and WC), WC* whole cerebellum (average of CGM and cerebellar WM); ¹personal communication