Table 3.
Median and 95th percentile of Aβ metrics calculated in elderly healthy controls (n = 122 for PET-only analytical methods; n = 88 for analytical methods using T1-weighted MRI) that were visually assessed as Aβ-negative by five independent blinded readers
| Software | Metric | Median | 95th percentile |
|---|---|---|---|
| #1 MIMneuro | Centiloid | 5.01 | 25.09 |
| #2 Hermes BRASS | SUVR | 1.17 | 1.29 |
| #3 Neurocloud | SUVR | 1.08 | 1.28 |
| #4 Standard centiloid | Centiloid | 2.07 | 20.94 |
| #5 Neurology Toolkit | Centiloid | 5.56 | 22.97 |
| #6 Neurology Toolkit | Amyloid index | − 0.44 | − 0.30 |
| #7 SPM8 (WC) | SUVR | 1.09 | 1.21 |
| #8 SPM8 (WC*) | SUVR | 0.88 | 0.98 |
| #9 SPM8 (CGM) | SUVR | 1.18 | 1.33 |
| #10 SPM8-PET only (WC) | Centiloid | 4.57 | 22.52 |
| #11 PMOD Neuro | SUVR | 1.18 | 1.32 |
| #12 CapAIBL | Centiloid | 1.81 | 18.32 |
| #13 NMF CapAIBL | Centiloid | 2.95 | 17.59 |
| #14 AmyloidIQ (PET only) | Amyloid load | 18.30 | 28.14 |
| #15 AmyloidIQ (MR) | Amyloid load | 16.30 | 24.36 |
CGM cerebellar gray matter, NMF non-negative matrix factorisation, SPM statistical parametric mapping, SUVR standardized uptake value ratio, WC whole cerebellum (volume weighted average of CGM and WC), WC* whole cerebellum (average of CGM and cerebellar WM)