TABLE 3.

Pharmacostatistical model and parameter estimates^a

Model	Equation
Pharmacokinetics	TVCL = θ1b
	TVV = θ2b
	CL = TVCL · EXP(η1)c
	V = TVV · EXP(η2)c
Errord	y = F + F · ɛ1
Mean parameter estimates (% CV)	CL/F = 0.19 liter/h/kg (range, 0.11–0.30 liter/h/kg) (23.8)
	V/F = 1.18 liters/kg (range, 0.43–1.92 liters/kg) (54.0)
	Residual variability = 20.6%

^aAbbreviations θ, variables representing parameter values; η, proportional differences from typical values; ɛ, difference (proportional) between observed and predicted concentrations; CL, clearance; V, volume of distribution; Y, observed concentration; F, predicted concentration. 

^bTypical value of clearance divided by predicted concentration or volume of distribution divided by predicted concentration (population estimate). 

^cIndividual estimate of clearance divided by predicted concentration or volume of distribution divided by predicted concentration. 

^dProportional error model.