Table 3.
Associations of laboratory parameters with variables of microcirculation
| a. Arteriolar venular ratio (AVR) as the dependent variable | |||
|---|---|---|---|
| Characteristics | Multivariateb | R2/R2 adjusted | |
| β-Coefficient | P-value | ||
| D Dimer (ug/I) | − 0.0002 | 0.028* | 0.37/0.23 |
| Thrombocytes (G/l) | 0.0003 | 0.26 | 0.27/ 0.12 |
| vWF (%) | − 0.0005 | 0.09 | 0.33/0.21 |
| TAG (mg/dl) | − 0.0005 | 0.031* | 0.36 / 0.23 |
| Cholesterol(mg/dl) | 0.0003 | 0.33 | 0.28/0.14 |
| Ferritin (mg/dl) | − 0.0003 | 0.083 | 0.34/0.21 |
| CXCL10 (pg/ml) | − 0.001 | 0.014* | 0.38/ 0.26 |
| IL-8 (fg/ml) | − 0.000003 | 0.82 | 0.25/0.11 |
| IL-6 (pg/ml) | − 0.001 | 0.36 | 0.29/0.16 |
| MCP-1 (pg/ml) | − 0.0001 | 0.68 | 0.25/0.11 |
| CRP (mg/dl) | 0.016 | 0.64 | 0.26/0.11 |
| ICAM-1(pg/ml) | − 0.0000006 | 0.96 | 0.27/0.14 |
| Leukocytes (G/l) | 0.006 | 0.43 | 0.25/0.10 |
| Neutrophils (%) | 0.0004 | 0.75 | 0.24/0.08 |
| Lymphocytes (%) | 0.0003 | 0.78 | 0.24/0.09 |
| Hb (g/dI) | − 0.009 | 0.61 | 0.24/0.09 |
| IgG (mg/dl) | − 0.00006 | 0.45 | 0.27/0.10 |
| IgG4 (mg/dl) | 0.0003 | 0.32 | 0.29/0.15 |
| b. Central retinal arteriolar equivalent (CRAE) as the dependent variable | |||
|---|---|---|---|
| Characteristics | Multivariateb | ||
| β-Coefficient | P-value | R2/R2 adjusted | |
| D Dimer (ug/I) | − 0.05 | 0.008** | 0.34 /0.20 |
| Thrombocytes(G/I) | 0.05 | 0.33 | 0.26 0.12 |
| vWF(%) | − 0.05 | 0.36 | 0.20/0.05 |
| TAG (mg/dl) | − 0.13 | 0.004** | 0.42/ 0.31 |
| Cholesterol (mg/dl) | 0.014 | 0.80 | 0.24/0.09 |
| Ferritin (mg/dl) | − 0.08 | 0.069 | 0.28/0.14 |
| CXCL10 (pg/ml) | − 0.06 | 0.63 | 0.18/ 0.02 |
| IL-8 (fg/ml) | − 0.004 | 0.22 | 0.21/0.06 |
| IL-6 (pg/ml) | 0.2 | 0.44 | 0.18/ 0.03 |
| MCP-1 (pg/ml) | − 0.07 | 0.35 | 0.20/0.04 |
| CRP (mg/dl) | 8.4 | 0.25 | 0.27/ 0.13 |
| ICAM-1 (pg/ml) | − 0.001 | 0.66 | 0.18/032 |
| Leukocytes (G/I) | 1.44 | 0.35 | 0.26/0.11 |
| Neutrophils (%) | 0.17 | 0.61 | 0.23/0.07 |
| Lymphocytes (%) | − 0.008 | 0.97 | 0.24/0.08 |
| Hb(g/dI) | − 3.02 | 0.43 | 026/0.11 |
| IgG (mg/dl) | 0.0002 | 0.99 | 0.22/0.07 |
| IgG4 (mg/dl) | 0.16 | 0.047a | 0.32/0.19 |
| c. Central retinal venular equivalent (CRVE) as the dependent variable | |||
|---|---|---|---|
| Characteristics | Multivariateb | R2/R2 adjusted | |
| β-Coefficient | P-value | ||
| D Dimer (ug/I) | − 0.01 | 0.40 | 0.18/0.007 |
| Thrombocytes(G/I) | 0.01 | 0.77 | 0.35 0.22 |
| vWF(%) | − 0.05 | 0.39 | 0.25/0.11 |
| TAG (mg/dl) | − 0.04 | 0.34 | 0.35/0.22 |
| Cholesterol (mg/dl) | − 0.05 | 0.31 | 0.35/0.22 |
| Ferritin (mg/dl) | − 0.07 | 0.087 | 0.20/0.03 |
| CXCL10 (pg/ml) | 0.3 | 0.020* | 0.35/0.22 |
| IL-8 (fg/ml) | − 0.006 | 0.054 | 0.31/0.17 |
| IL-6 (pg/ml) | 0.6 | 0.040* | 0.32/0.20 |
| IgG4 (mg/dl) | 0.09 | 0.25 | 0.34/0.21 |
| MCP-1(pg/ml) | − 0.05 | 0.49 | 0.23/0.08 |
| CRP (mg/dl) | 5.9 | 0.35 | 0.35/0.22 |
| ICAM-1 (pg/ml) | − 0.001 | 0.62 | 0.23/0.10 |
| Leukocytes (G/I) | 0.26 | 0.84 | 0.35/0.21 |
| Neutrophils (%) | 0.13 | 0.63 | 0.36/0.22 |
| Lymphocytes (%) | − 0.17 | 0.51 | 0.35/0.23 |
| Hb(g/dI) | − 1.5 | 0.64 | 0.34/0.22 |
| IgG (mg/dl) | 0.015 | 0.37 | 0.33/0.20 |
| IgG4 (mg/dl) | 0.9 | 0.25 | 0.34/0.21 |
The multivariate linear regression model shows associations of laboratory parameters with the dependent variables AVR, CRAE, CRVE. D-Dimer was measured in n = 36, thrombocytes, leukocytes neutrophils, lymphocytes, hemoglobin (Hb) and ferritin in n = 37, CRP (C-reactive protein), Cholesterol, TAG, CXCL10, IL8, IL-6, IgG, IgG4 and MCP-1 in n = 38. Von Willebrand factor (vWF) and ICAM-1 in n = 40. In the multivariate modelb, age, gender, obesity, arterial hypertension and nicotine abuse were included. The respective R2 are shown for the multivariate modelb after correction. For modela F-statistic was not significant