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. 2023 Sep 29;8:144. doi: 10.1038/s41541-023-00733-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a T cell receptor (TCR) clonotype size of CD8⁺ T cells projected onto t-SNE. Blue circle indicates effector subsets, purple circle indicates exhausted subsets. b Distribution of expanded (clone size ＞ 1) and non-expanded (clone size = 1) TCR clonotype of CD8⁺ T cells projected onto t-SNE. c Distribution of TCR cell frequencies among clusters measured in the spleens and tumors, respectively. The median is shown by the center line within the box of box plots, while the lower and upper box boundaries reflect the 25th and 75th percentiles, respectively, with whiskers drawn to the number that is closest to but still falls within the 1.5 interquartile range from top to bottom of the box borders. d Distribution of TCR clonotype (clone size ≥30) size of CD8⁺ T cells in the spleens and tumors. The TCR label indicates the numeric ID of each clonotype (the former number) and the number of cells belonging to the clonotype (the latter number), respectively. e TCR-wise cell counts of top clonotypes across clusters in the spleens and tumors, respectively. Spleens were harvested from non-TB mice and tumors were harvested from TB. Data is derived from the therapeutic study in Fig. 4. TB tumor bearing.