Table 7.
Cost values
| Costs | Value | Confidence interval | Distribution | Source/assumptions |
|---|---|---|---|---|
| Mia® Costs | ||||
| Set-up costs | £35,000 | - | Fixed | Kheiron technologies, per Site |
| Maintenance costs | 0 | - | Fixed | Kheiron technologies. Cost is included in the set-up costs |
| Cost per scan | £4.72 | - | Fixed | Kheiron technologies |
| Costs of standard practice | ||||
| Radiologist | £110 | - | Fixed | Cost per hour of patient contact (PSSRU 2019). Cost per scan: (£5.88) based on 27 scans per working hour |
| Mammography (both breasts) | £184 | - | fixed | 4 scans (one of each breast for two readers) Patient Level Information Costing System (PLICS) Leeds (2020) |
| Assessments costs (during recall; both interventions) | ||||
| Biopsy and exploration | £452 | - | Fixed | Weighted average between different biopsy procedures (core needle biopsy, ultrasound-guided biopsy, fine needle aspiration, etc). National Schedule of NHS Costs Year: 2018-19 - All NHS trusts and NHS foundation trusts - HRG Data |
| Mammography | £46 | - | Fixed | Cost per scan PLICS Leeds (2020) |
| Ultrasound (with no contrast) | £52 | - | Fixed | National Schedule of NHS Costs (2018-19) |
| Triple assessment (overall) | £314 | - | Fixed | Cost-per-patients assumed that the same proportion of patients (14%) will receive either the three assessments (biopsy, mammography, and ultrasound), a combination of two (i.e. biopsy and mammography; biopsy and ultrasound), or just one procedure. |
| Consultant oncologist | £52.9 | - | Fixed | Once cancer is detected. Assumed 20 min consultation (PSSRU 2019). |
| MRI | £148.40 | - | Fixed | To determine the stage of the cancer. National Schedule of NHS Costs–Year 2018-19 |
| Costs of cancer treatment | ||||
| DCIS | £8,968 | £9,692-£10,471 | Lognormal | Assumed as treatment cost for 6 months of a grade 1 cancer. Hall et al.15 |
| NPI I 1st year | £10,471 | £8,665-£12,615 | Lognormal | Estimated yearly based on Hall et al.15 |
| NPI II 1st year | £15,484 | £13,548-£17,614 | Lognormal | Estimated yearly based on Hall et al.15 |
| NPI III 1st year | £21,951 | £19,044-£24,882 | Lognormal | Estimated yearly based on Hall et al.15 |
| NPI I–II 2nd to 9th year | £2,819 | - | Fixed | Average per year estimated by Laudicella et al.25 between years 2 and 9 |
| NPI III 2nd to 9th year | £3,815 | - | Fixed | Average per year estimated by Laudicella et al.25 between years 2 and 9 |
| Advanced cancer costs (6 months) | £14,984 | £13,161-£16,839 | Lognormal | Assumed as 6 months costs of a grade 3 cancer Hall et al.15 |
| Advanced cancer (12 months) | £21,951 | £19,044-£24,882 | Lognormal | Assumed as yearly costs of grade 3 cancer Hall et al.15 |
| Palliative care | £14,827 | £1,472-£45,326 | Lognormal | Average cost over 372 survival days. The model uses these figures to estimate the monthly cost of palliative care. |