TABLE 1.
MICs, times of exposure to antimicrobial agent, and in vitro PAEs, SMEs, and PA SMEs of isepamicin and azithromycin against S. aureus and E. coli
| Antimicrobial agent and microorganism | MIC (mg/liter) | Concn (mg/liter) | Time preexposure (h) | PAE (h) | SME (h) at indicated fraction of MIC
|
PA SME (h) at indicated fraction of MIC
|
||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1/2 | 1/4 | 1/8 | 1/2 | 1/4 | 1/8 | |||||
| Isepamicin | ||||||||||
| S. aureus | 2 | 7 | 1 | 2.30 | 6.11 | 5.91 | 4.62 | >9.28 | >9.28 | 8.00 |
| E. coli | 2 | 7 | 0.5 | 1.50 | 1.97 | 1.93 | 1.72 | 4.23 | 3.77 | 3.38 |
| Azithromycin | ||||||||||
| S. aureus | 2 | 20 | 1 | 2.20 | 4.51 | 3.74 | 3.49 | >8.08 | >8.08 | >8.08 |
| E. coli | 8 | 80 | 1.5 | 3.50 | 4.74 | 4.28 | 3.87 | >7.64 | >7.64 | 6.92 |