TABLE 2.
Doses, pharmacokinetic parameters, times that levels of antimicrobial agent in serum exceeded the MIC, in vivo PAEs, and in vivo SMEs of isepamicin and azithromycin against S. aureus and E. coli
| Antimicrobial agent and microorganism | Peak drug level (μg/ml) | Time for peak level (h) | AUC (mg/liter · h) | Dose (mg/kg) | T>MIC (h) | In vivo PAE (h)a | PAE/T>MIC (h) | In vivo SME (h)a |
|---|---|---|---|---|---|---|---|---|
| Isepamicin | ||||||||
| S. aureus | 37.47 | 0.5 | 22.75 | 7 | 1.1 | 3.6 ± 0.4 | 3.27 | −0.8 ± 0.4 |
| E. coli | 37.47 | 0.5 | 22.75 | 7 | 1.1 | 3.0 ± 0.4 | 2.72 | −0.1 ± 0.3 |
| Azithromycin | ||||||||
| S. aureus | 7.89 | 0.25 | 19.34 | 20 | 4.5 | 3.5 ± 0.5 | 0.77 | 1.75 ± 0.2 |
| E. coli | 82.61 | 1.00 | 96.89 | 80 | 1.7 | 3.5 ± 0.5 | 2.05 | 1.22 ± 0.1 |
a
Each value represents the mean of three experiments ± standard error.