TABLE 3.
Total doses administered and lethal effects of two different administrations of isepamicin and azithromycin against S. aureus and E. coli on in vivo killing kinetics
| Antimicrobial agent and microorganism | Schedule A
|
Schedule B
|
Difference between schedules A and B
|
|||
|---|---|---|---|---|---|---|
| Lethal effecta (log10 CFU) | Total dose (mg/kg) | Lethal effect (log10 CFU) | Total dose (mg/kg) | Lethal effect (log10 CFU) | Total dose (mg/kg) | |
| Isepamicin | ||||||
| S. aureus | −4.13 ± 0.3 | 70 | −3.73 ± 0.4 | 14 | −0.40 | 56 |
| E. coli | −4.68 ± 0.4 | 70 | −4.58 ± 0.5 | 14 | −0.10 | 56 |
| Azithromycin | ||||||
| S. aureus | −2.81 ± 0.4 | 60 | −2.44 ± 0.3 | 40 | −0.37 | 20 |
| E. coli | −2.41 ± 0.4 | 400 | −2.09 ± 0.5 | 160 | −0.32 | 240 |
a
Difference in log10 CFU between control and treated growth curves at the end of the in vivo killing kinetics.