Table 1.
All reported cases of cryptococcal endophthalmitis in solid organ transplant recipients in the literature.
| Author | Year | Age | Gender | Affected side | Transplant Type | Baseline Immunosuppression | VA on presentation | Diagnostic Method | Systemic Treatment and duration | Intravitreal Treatment and duration | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Agarwal | 1991 | 37 | M | Bilateral | Renal | Azathioprine 125mg/day and prednisolone 15mg/day | Right 6/6 and Left 6/36 | Positive India ink stain on CSF | 6weeks of amphotericin B - total dose 1.75g. Changed to fluconazole 200mg/day for 8 weeks, then 100mg/day as ongoing maintenance therapy | Nil | 6/5 and 6/24 |
| Biswas | 1998 | 37 | M | Left | Renal | Azathioprine 100mg PO followed by Cyclosporine 200mg; Prednisolone 10mg PO | Blurred | CSF from LP | IV Fluconazole 200mg/day for 10 weeks. Then 200mg/day PO for 4 weeks. | IVT amphotericin B after 6months fluconazole added. | Right Eye 6/6 and Left eye eviscerated |
| Present Report | 2022 | 59 | M | Left | Renal | Tacrolimus 1mg mane and 0.5mg nocte; Mycophenolate mofetil 500mg BD; Prednisolone 5mg mane | 6/7.5 | Crytococcal antigen lateral flow assay on diluted vitreous. Titre 1:80 | IV liposomal amphotericin 3mg/kg/day and Flucytosine 25mg/kg QID for 9 days. Then oral fluconazole 400mg/day. | Amphotericin B twice weekly for 6 weeks and then weekly for 7months until quiescent | 6/60 + 1 |