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. 2023 Sep 26;32:12–27. doi: 10.1016/j.bioactmat.2023.09.007

Fig. 4.

Fig. 4

Intravenous administration of GM-CSF-IL-7-VNP20009 caused eliminatable inflammation. (A) (B) (C) and (D) Blood routine test showed the concentration of white blood cell, monocyte, lymphocyte and neutrophil at different time points after GM–CSF–IL-7-VNP20009 injection (n = 3). Error bar, mean ± s.d. (E) and (F) ELISA assay showed the blood TNF-α and IL-6 concentration at different time points after GM–CSF–IL-7-VNP20009 injection (n = 3). Error bar, mean ± s.d. (G) (H) and (I) The effect of GM–CSF–IL-7-VNP20009 intravenous injection on the TNF-α, GM-CSF and IL-7 concentration in mouse tissues (n = 3). Error bar, mean ± s.d. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. The statistics were analyzed by Student's t-test.