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. 2023 Apr 11;56(10):e13476. doi: 10.1111/cpr.13476

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© 2023 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Constitutively activated AMPKα1 promotes bone‐derived IGF‐1 production and activates IGF‐1 signalling pathway. (A) Schematic illustration of experimental design of sample preparation for RNA sequencing. (B) Top 5 differentially expressed genes (DEGs) in sequencing. FPKM = Fragments Per Kilobase Million. (C) ELISA showing IGF‐1 protein concentrations in mouse bone marrow and primary‐mesenchymal stem cell (MSC) supernatant (n = 6). (D) ELISA showing IGF‐1 protein concentrations in C3H10T1/2 cell supernatant (n = 6). (E) Effects of constitutively activated AMPKα1 on IGF‐1 signalling pathway in primary MSCs. (F, G) Effects of AMPKα1 constitutive activation or AMPKα1 knockdown on IGF‐1 signalling pathway in C3H10T1/2 cells. Results are presented as bar plots with all data points. *p < 0.05; **p < 0.01.