Fig. 1.

Dysosmobacter welbionis J115^T alleviates diet-induced obesity along with an improvement of the glucose intolerance. (A and B) Body weight and fat mass evolution during 10 weeks of mice fed a normal (ND) or high-fat diet (HFD) either treated with a daily oral gavage of vehicle or live D. welbionis J115^T 1×10⁹ colony-forming units (cfus) frozen in trehalose. (C) Weight at the end of the 10 weeks of the white adipose tissues: visceral AT, epididymal AT, subcutaneous AT, and brown AT. (D) Plasma glucose profile during a two-hour oral glucose tolerance test (OGTT). (E) Plasma insulin levels 30 min before and 15 min after glucose administration. (F) Insulin resistance index. Number of mice per group: 9–10. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test for figure parts C–E and two-way ANOVA followed by Tukey’s post hoc test for figure parts A, B, and D. ∗P < 0.05; ∗∗P < 0.01; and ∗∗∗P < 0.001. Results are represented as bar plots with mean±SEM for figure parts C, E, and F. In figure A and B, ∗ are for comparisons between the high-fat diet (HFD) versus HFD + J115 group and # are for comparisons for the HFD and the control (CT) or for the HFD+J115 and the CT.