Recommendation 5: In adults with CIC, the panel recommends the use of bisacodyl or sodium picosulfate (SPS) short term or as rescue therapy over management without bisacodyl or SPS (strong recommendation, moderate certainty of evidence).

Implementation considerations Short-term use is defined as daily use for 4 weeks or less. While long-term use is probably appropriate, data are needed to better understand tolerance and side effects. This is a good option for occasional use or rescue therapy in combination with other pharmacological agents for CIC. The most common side effects are abdominal pain, cramping and diarrhea. The panel suggests starting at a lower dose and increasing the dose as tolerated.