TABLE 1.
Pharmacokinetic parameters following a 200-mg oral dose of clinafloxacin
| Pharmaco- kinetic parameter | Plasma
|
Inflammatory fluid
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmax (h) | t1/2 (h) | AUC0–∞ (μg · h/liter) | Apparent vol of distribution (liter) | CL/F (ml/min) | % of drug recovered in urine
|
Cmax (μg/ml) | Tmax (h) | t1/2 (h) | AUC0–∞ (μg · h/liter) | % Pene- tration | ||
| 0–24 h | 0–48 h | ||||||||||||
| Mean | 1.34 | 1.78 | 5.65 | 9.86 | 166.3 | 341.7 | 58.8 | 71.8 | 1.13 | 3.8 | 4.6 | 9.22 | 93.1 |
| SD | 0.32 | 0.83 | 0.72 | 1.13 | 19.4 | 41.7 | 3.16 | 3.3 | 0.31 | 1.3 | 1.5 | 2.21 | 16.1 |
| Minimum | 1.01 | 1 | 4.90 | 7.98 | 138.6 | 301.7 | 55.2 | 66.2 | 0.78 | 3 | 2.2 | 6.80 | 70.5 |
| Maximum | 1.95 | 3 | 7.31 | 11.04 | 198.4 | 418.3 | 63.1 | 75.7 | 1.69 | 6 | 5.2 | 12.63 | 117.2 |