Table 4.

Subgroup analysis of TyG index and mortality in patients with T2D.

Cutoff value	N	All-cause mortality		P for log likelihood ratio test	CVD mortality		P for log likelihood ratio test
		HR (95% CI), p value			HR (95% CI), p value
		< 8.95	≥ 8.95		< 9.00	≥ 9.00
Age, years
≥ 65	1444	0.75 (0.51, 1.10), 0.135	1.28 (1.03, 1.60), 0.027	0.007	0.85 (0.44, 1.63), 0.621	1.49 (1.00, 2.22), 0.050	0.065
< 65	1554	0.90 (0.46, 1.75), 0.750	1.15 (0.92, 1.44), 0.215	0.369	0.48 (0.14, 1.63), 0.238	1.18 (0.76, 1.81), 0.458	0.144
Gender
Male	1594	0.87 (0.57, 1.34), 0.535	1.18 (0.96, 1.46), 0.116	0.047	0.78 (0.35, 1.70), 0.526	1.64 (1.14, 2.35), 0.007	0.021
Female	1404	0.59 (0.34, 1.01), 0.056	1.34 (1.05, 1.71), 0.017	0.018	0.69 (0.26, 1.83), 0.457	1.19 (0.72, 1.98), 0.498	0.249
HbA1c, %
< 6.5	1115	0.92 (0.58, 1.46).0.723	1.18 (0.74, 1.87), 0.495	0.401	1.15 (0.49, 2.70), 0.740	1.21 (0.47, 3.12), 0.698	0.768
≥ 6.5	1883	0.65 (0.40, 1.06), 0.085	1.28 (1.08, 1.52), 0.004	0.009	0.59 (0.26, 1.32), 0.200	1.44 (1.06, 1.97), 0.022	0.026
BMI, kg/m2
< 25	530	0.63 (0.33, 1.20), 0.158	1.40 (0.95, 2.04), 0.086	0.014	0.47 (0.10, 2.22), 0.341	1.74 (0.79, 3.83), 0.170	0.209
≥ 25	2468	0.88 (0.59, 1.32), 0.542	1.32 (1.11, 1.57), 0.002	0.077	0.76 (0.40, 1.43), 0.390	1.50 (1.09, 2.06), 0.013	0.042
Smoking status
Yes	1549	0.87 (0.56, 1.36), 0.551	1.29 (1.06, 1.57), 0.010	0.021	0.74 (0.35, 1.59), 0.439	1.77 (1.23, 2.54), 0.002	0.012
No	1449	0.57 (0.34, 0.96), 0.033	1.26 (0.97, 1.63), 0.080	0.014	0.67 (0.27, 1.66), 0.388	1.25 (0.78, 2.02), 0.355	0.178

All subgroups were adjusted for age, sex, education level, race/ethnicity, PIR, smoking status, drinking status, BMI, CHD, HF, heart attack, stroke, angina, hypertension, hyperlipidemia, glucose-lowering medication use, HbA1c, LDL-C, and TC. We excluded stratification variables from the model in the analysis of single subgroups.