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. 2023 Jun 22;108(10):2582–2593. doi: 10.3324/haematol.2023.283057

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Figure 2. — Schematic representation of normal and β-thalassemic erythropoiesis. A few consequences associated with ineffective erythropoiesis in β-thalassemia, such as iron overload and hepatosplenomegaly, are presented. EPO: erythropoietin; TF: transferrin; ERFE: erythroferrone; EPOR: erythropoietin receptor; TFR: transferrin receptor; JAK2: Janus kinase 2; BMP: bone morphogenetic protein; HJV: hemojuvelin; TMPRSS6: transmembrane protease, serine 6; HFE: homeostatic iron regulator; SMAD: small mothers against decapentaplegic; HAMP: hepcidin antimicrobial protein.