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. 2023 Apr 6;108(10):2652–2663. doi: 10.3324/haematol.2022.282418

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Figure 5. — Restored gene expression of key pathways of CD34⁺ cells commited to the monocyte lineage in corrected hematopoietic stem and progenitor cells from gene therapy-treated Fanconi anemia patients. (A) Up-regulated and down-regulated genes implicated in cell cycle control. The figure represents the logFC associated to two contrasts (see Contrast box): FANCA⁺ versus FANCA^-hematopoietic stem and progenitor cells (HSPC) from gene therapy (GT)-treated Fanconi anemia (FA) patients (internal crowns), and healthy donor (HD) HSPC versus FANCA^- HSPC from GT-treated patients (external crowns). Each external and internal crown is divided in four parts (see Sample box), each of them representing one FA patient. Up-regulated genes are shown in red and down-regulated genes in blue. (B) Same representation as in (A) showing changes in the expression of genes participating in the FA/BRCA pathway.