Table 1.

Phenotype methods and their features

Method	Control objective(s)	Control action(s)	Requirements	References
Algebraic methods	Transform transient state into a steady state; Transform steady state into a transient state; Eliminate transition between two states	Assign node to specified value; Activate or inhibit specific edge	Regulatory network structure; Boolean functions written as polynomials	Murrugarra et al. (Sep 2016); Vieira et al. (2020)
Control Kernel	Force the system to have one stable attractor	Assign node to specified value	Boolean functions written as polynomials	Choo et al. (2018); Borriello and Daniels (2021)
Feedback Vertex Set	Force the system to have one stable attractor	Assign node to its value in the target attractor	Regulatory network structure; Node activities in target attractor	Mochizuki et al. (2013); Zañudo et al. (2017)
Stable Motifs	Force any initial state toward a pre-existing attractor; Transform a steady-state into a transient state	Assign node to its stable motif value; Inhibit interaction to disrupt stable motif of a steady-state	Regulatory network structure; Boolean rules written in DNF	Zañudo and Albert (2015)

This table contains a summary of the target identification techniques discussed, as well as their key features. Namely, we summarize their objectives, induced control actions, and the necessary components to use each method. Software for these methods can be found in the “Appendix”