Table 8.
Functions for large T-LGL model
| Node | Rule |
|---|---|
| CTLA4 | TCR |
| TCR | Stimuli and not CTLA4 |
| PDGFR | S1P or PDGF |
| FYN | TCR or IL2RB |
| Cytoskeleton_signaling | FYN |
| LCK | CD45 or ((TCR or IL2RB) and not ZAP70) |
| ZAP70 | LCK and not FYN |
| GRB2 | IL2RB or ZAP70 |
| PLCG1 | GRB2 or PDGFR |
| KRAS | (GRB2 or PLCG1) and not GAP |
| GAP | (KRAS or (PDGFR and GAP)) and not (IL15 or IL2) |
| MEK | KRAS |
| ERK | MEK and PI3K |
| PI3K | PDGFR or KRAS |
| NFKB | (TPL2 or PI3K) or (FLIP and TRADD and IAP) |
| NFAT | PI3K |
| RANTES | NFKB |
| IL2 | (NFKB or STAT3 or NFAT) and not TBET |
| IL2RBT | ERK and TBET |
| IL2RB | IL2RBT and (IL2 or IL15) |
| IL2RAT | IL2 and (STAT3 or NFKB) |
| IL2RA | (IL2 and IL2RAT) and not IL2RA |
| JAK | (IL2RA or IL2RB or RANTES or IFNG) and not (SOCS or CD45) |
| SOCS | JAK and not (IL2 or IL15) |
| STAT3 | JAK |
| P27 | STAT3 |
| Proliferation | STAT3 and not P27 |
| TBET | JAK or TBET |
| CREB | ERK and IFNG |
| IFNGT | TBET or STAT3 or NFAT |
| IFNG | ((IL2 or IL15 or Stimuli) and IFNGT) and not (SMAD or P2) |
| P2 | (IFNG or P2) and not Stimuli2 |
| GZMB | (CREB and IFNG) or TBET |
| TPL2 | TAX or (PI3K and TNF) |
| TNF | NFKB |
| TRADD | TNF and not (IAP or A20) |
| FasL | STAT3 or NFKB or NFAT or ERK |
| FasT | NFKB |
| Fas | (FasT and FasL) and not sFas |
| sFas | FasT and S1P |
| Ceramide | Fas and not S1P |
| DISC | FasT and ((Fas and IL2) or Ceramide or (Fas and not FLIP)) |
| Caspase | (((TRADD or GZMB) and BID) and not IAP) or DISC |
| FLIP | (NFKB or (CREB and IFNG)) and not DISC |
| A20 | NFKB |
| BID | (Caspase or GZMB) and not (BclxL or MCL1) |
| IAP | NFKB and not BID |
| BclxL | (NFKB or STAT3) and not (BID or GZMB or DISC) |
| MCL1 | (IL2RB and STAT3 and NFKB and PI3K) and not DISC |
| Apoptosis | Caspase |
| GPCR | S1P |
| SMAD | GPCR |
| SPHK1 | PDGFR |
| S1P | SPHK1 and not Ceramide |
| PDGF | 0 |
| IL15 | 1 |
| Stimuli | 1 |
| Stimuli2 | 0 |
| CD45 | 0 |
| TAX | 0 |