Table 1:
Univariate analysis of factors associated with upgrade at excision
| Variable | Overall (n=208) n (%) | No Upgrade (n=177) n (%) | Upgrade (n=31) n (%) | p-value |
|---|---|---|---|---|
| Age | 0.094 | |||
| <50 years | 70 (34%) | 55 (31%) | 15 (48%) | |
| ≥50 years | 138 (66%) | 122 (69%) | 16 (52%) | |
| Imaging modality | 0.7 | |||
| Mammogram | 159 (76%) | 137 (77%) | 22 (71%) | |
| MRI | 36 (17%) | 29 (16%) | 7 (23%) | |
| Ultrasound | 13 (6.2%) | 11 (6.2%) | 2 (6.5%) | |
| Target lesion diameter | <0.001 | |||
| Median (IQR) | 7 (4, 13) | 6 (4, 12) | 10 (7, 28) | |
| Number of cores removed | 0.8 | |||
| Median (IQR) | 8 (6, 9) | 8 (6,9) | 8 (6,9) | |
| Needle gauge | 0.5 | |||
| 9 | 183 (88%) | 157 (89%) | 26 (84%) | |
| 10 | 3 (1.4%) | 2 (1.1%) | 1 (3.2%) | |
| 11 | 3 (1.4%) | 3 (1.7%) | 0 (0%) | |
| 12 | 12 (5.8%) | 9 (5.1%) | 3 (9.7%) | |
| 13 | 2 (1.0%) | 2 (1.1%) | 0 (0%) | |
| 14 | 5 (2.4%) | 4 (2.3%) | 1 (3.2%) | |
| Target fully removed by CNB | 0.027 | |||
| Yes | 73 (35%) | 68 (38%) | 5 (16%) | |
| No | 135 (65%) | 109 (61%) | 26 (84%) | |
| Extent of ADH | 0.006 | |||
| Focal | 98 (47%) | 91 (51%) | 7 (23%) | |
| Non-focal | 110 (53%) | 86 (49%) | 24 (77%) | |
| Co-existing atypia in CNB | ||||
| FEA | 43 (21%) | 34 (19%) | 9 (29%) | 0.3 |
| Lobular neoplasia | 42 (20%) | 36 (20%) | 6 (19%) | >0.9 |
| Prior/concurrent breast carcinoma | 0.4 | |||
| Yes | 82 (39%) | 67 (38%) | 15 (48%) | |
| No | 126 (61%) | 110 (62%) | 16 (52%) | |
IQR – interquartile range, CNB – core needle biopsy, ADH – atypical ductal hyperplasia, FEA – flat epithelial atypia