Table 2:
Univariate analysis of factors associated with upgrade at excision in focal ADH cohort
| Variable | Overall (n=98) n (%) | No Upgrade (n=91) n (n%) | Upgrade (n=7) n (n%) | p-value |
|---|---|---|---|---|
| Age | 0.2 | |||
| <50 years | 32 (33%) | 28 (31%) | 4 (57%) | |
| ≥50 years | 66 (67%) | 63 (69%) | 3 (43%) | |
| Imaging modality | 0.2 | |||
| Mammogram | 80 (82%) | 74 (81%) | 6 (86%) | |
| MRI | 13 (13%) | 13 (14%) | 0 (0%) | |
| Ultrasound | 5 (5.1%) | 4 (4.4%) | 1 (14%) | |
| Imaging target | 0.6 | |||
| Calcifications | 78 (80%) | 72 (79%) | 6 (86%) | |
| Mass | 7 (7.1%) | 6 (6.6%) | 1 (14%) | |
| Non-mass enhancement | 9 (9.2%) | 9 (9.9%) | 0 (0%) | |
| Mass enhancement | 4 (4.1%) | 4 (4.4%) | 0 (0%) | |
| Target lesion diameter | 0.15 | |||
| 1–5 mm | 46 (47%) | 44 (49%) | 2 (29%) | |
| 6–10 mm | 30 (30%) | 25 (27%) | 5 (71%) | |
| 11–20 mm | 15 (15%) | 15 (17%) | 0 (0%) | |
| >20 mm | 7 (7.2%) | 7 (7.8%) | 0 (0%) | |
| Target fully removed by CNB | 0.7 | |||
| Yes | 37 (38%) | 35 (38%) | 2 (29%) | |
| No | 61 (62%) | 56 (62%) | 5 (71%) | |
| Co-existing atypia in CNB | ||||
| FEA | 20 (20%) | 16 (18%) | 4 (57%) | 0.03 |
| Lobular neoplasia | 27 (28%) | 25 (27%) | 2 (29%) | >0.9 |
| Prior/concurrent breast carcinoma | >0.9 | |||
| Yes | 34 (35%) | 32 (35%) | 2 (29%) | |
| No | 64 (65%) | 59 (65%) | 5 (71%) | |
CNB – core needle biopsy, ADH – atypical ductal hyperplasia, FEA – flat epithelial atypia