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. 2015 Nov 11;2015(11):CD010435. doi: 10.1002/14651858.CD010435.pub2

Daoud 1999.

Methods Quasi‐randomised clinical trial, conducted in Jordan between January 1993 and December 1995
Alternate allocation was used
Participants 52 full‐term neonates. Diagnosis of meningitis was suspected on the basis of clinical picture and CSF abnormalities: pleocytosis (> 30 leucocytes/mL), raised protein (> 100 mg/100 mL) and reduced CSF to blood sugar ratio < 0.5
Interventions Dexamethasone administered at a dose of 0.15 mg per kg every 6 hours. Duration of administration was 4 days
Control group did not receive placebo. Both groups were treated with cefotaxime
Steroids were administered about 10 to 15 minutes before antibiotics
Outcomes Number of all‐cause deaths until hospital discharge, number of infants with sensorineural deafness at two years of age, number of participants with developmental delay, number of participants with seizures at any time, number of participants with hydrocephalus
Notes Ethical approval was obtained from the Jordan University of Science and Technology
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Alternate allocation was used
Allocation concealment (selection bias) Unclear risk This was not reported
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk This was not reported
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk This was not reported
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Only 1 participant was lost to follow‐up; 9 were excluded afterwards, as they were thought to have aseptic meningitis
Selective reporting (reporting bias) Low risk We have no reason to think that investigators selectively reported outcomes
Other bias Low risk This study was funded by a government university grant