Daoud 1999.
Methods | Quasi‐randomised clinical trial, conducted in Jordan between January 1993 and December 1995 Alternate allocation was used |
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Participants | 52 full‐term neonates. Diagnosis of meningitis was suspected on the basis of clinical picture and CSF abnormalities: pleocytosis (> 30 leucocytes/mL), raised protein (> 100 mg/100 mL) and reduced CSF to blood sugar ratio < 0.5 | |
Interventions | Dexamethasone administered at a dose of 0.15 mg per kg every 6 hours. Duration of administration was 4 days Control group did not receive placebo. Both groups were treated with cefotaxime Steroids were administered about 10 to 15 minutes before antibiotics |
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Outcomes | Number of all‐cause deaths until hospital discharge, number of infants with sensorineural deafness at two years of age, number of participants with developmental delay, number of participants with seizures at any time, number of participants with hydrocephalus | |
Notes | Ethical approval was obtained from the Jordan University of Science and Technology | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | Alternate allocation was used |
Allocation concealment (selection bias) | Unclear risk | This was not reported |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | This was not reported |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | This was not reported |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Only 1 participant was lost to follow‐up; 9 were excluded afterwards, as they were thought to have aseptic meningitis |
Selective reporting (reporting bias) | Low risk | We have no reason to think that investigators selectively reported outcomes |
Other bias | Low risk | This study was funded by a government university grant |