Table 2.
Hemodynamic and histological indices after 10 months of treatment.
| Sham (n = 10) | Control (n = 8) | R (n = 9) | |
|---|---|---|---|
|
| |||
| BM (g) | 672±21 | 676±12 | 682±11 |
| Hemodynamics | |||
| HR (beats/min) | 282±8 | 317±28 | 269±14 |
| ESV (μL) | 270±20 | 1121±143* | 910±46* |
| EDV (μL) | 556±20 | 1184±137* | 1049±42* |
| ESP (mmHg) | 93±4 | 86±5 | 89±4 |
| EDP (mmHg) | 4.2±0.5 | 6.4±1.6 | 4.0±0.3 |
| SV (μL) | 329±19 | 120±22* | 139±10* |
| EF (%) | 59±2 | 10±1* | 14±1* |
| CO (mL/min) | 94±7 | 39±8* | 37±3* |
| Ea (mmHg/μL) | 0.29±0.03 | 0.77±0.09* | 0.69±0.05* |
| +dP/dt (mmHg/sec) | 6809±283 | 4369±332* | 5381±299* |
| −dP/dt (mmHg/sec) | −7354±645 | −4265±427* | −4841±334* |
| Tau (ms) | 9.1±0.5 | 11.7±1.1* | 10.9±0.5 |
| PRSW (mmHg*μL/μL) | 69±4 | 40±5* | 60±3# |
| Ees (mmHg/μL) | 0.27±0.03 | 0.40±0.07 | 0.63±0.05*# |
| Eed (mmHg/μL) | 0.006±0.001 | 0.034±0.005* | 0.028±0.003* |
| Ea/Ees | 1.2±0.1 | 2.7±0.7* | 1.1±0.1# |
| Cardiac histology | |||
| MI size (% of LV) | N/A | 45±3 | 39±1 |
| HM/BM (g/kg) | 3.0±0.1 | 4.1±0.2* | 3.8±0.1* |
| Myocyte density in LVPW (mm−2) | 319±12 | 178±7* | 202±11* |
| Myocyte diameter of LVPW(μm) | 21±0 | 37±1* | 34±1* |
| Collagen fraction of LVPW (%) | 1.9±0.2 | 4.1±0.5* | 3.4±0.3* |
| Thoracic aorta histology | |||
| Lumen diameter (μm) | 3342±42 | 3523±61* | 3451±19 |
| Medium thickness (μm) | 266±9 | 250±2 | 248±5 |
| Collagen fraction of medium (%) | 11.2±1.0 | 9.1±0.7 | 9.2±0.6 |
Note: Data are mean ± SEM
*
p < 0.05 vs. Sham
#
p < 0.05 vs. Control.
Sham, sham operated; Control, myocardial infarct (MI) rats with normal diet; R, MI rats with resveratrol enriched diet. BM, body mass; HR, heart rate; ESV, end-systolic volume; EDV, end-diastolic volume; SV, stroke volume; EF, ejection fraction; CO, cardiac output; Ea, arterial elastance; tau, isovolumic relaxation time; PRSW, preload recruitable stroke work; Ees, systolic elastance; Eed, diastolic stiffness; HM/BM, heart mass to body mass ration; LVPW, LV posterior wall