Table 1.
Effects of acute pretreatment of mice with different doses of edaravone on the incidences of tonic seizures and mortality in intraperitoneal PTZ-induced model of seizure
| Groups (n=6) | Tonic seizure protection (%) | P value | Mortality protection (%) | P value |
|---|---|---|---|---|
| Vehicle | 44.40 | 44.40 | ||
| Edaravone (7.5 mg/Kg) | 42.91 | 0.41a | 42.91 | 0.41a |
| Edaravone (10 mg/Kg) | 42.93 | 0.32a | 42.93 | 0.32a |
| Edaravone (12.5 mg/Kg) | 71.42* | 0.03a | 71.42* | 0.03a |
Percentages of the protections against the incidences of tonic seizure and mortality subsequent to intraperitoneal injections of PTZ (85 mg/Kg) were compared between the studied groups using the Chi square test.
a
The group was compared with the vehicle group. *P≤0.05 was considered significant.