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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Biomaterials. 2023 Feb 20;296:122065. doi: 10.1016/j.biomaterials.2023.122065

Fig. 6. Engineered cell membrane-coated nanoparticles for cytosolic mRNA delivery.

Fig. 6.

(A) Cells are genetically modified for the surface expression of viral hemagglutinin (HA), which enables mRNA-loaded nanoparticles coated with the HA-expressing membrane (HA-mRNA-NP) to achieve endosomal escape after cellular uptake. (B,C) HA-mRNA-NP promote in vivo expression of a Cypridina luciferase-encoding payload after intranasal (B) or intravenous (C) administration. Adapted with permission [98]. Copyright 2021, Wiley-VCH.