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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Biomaterials. 2023 Feb 20;296:122065. doi: 10.1016/j.biomaterials.2023.122065

Fig. 8. Engineered cell membrane-coated nanoparticles for direct antigen presentation.

Fig. 8.

(A) Wild-type cancer cells are engineered to express a costimulatory signal alongside their native MHC-I antigens. Nanoparticles coated with the membrane derived from these engineered cells can generate anticancer immunity by directly activating tumor-specific T cells. (B) Prophylactic immunization with the engineered nanoparticles significantly slows tumor growth and improves survival in a murine cancer model. Adapted with permission [58]. Copyright 2020, Wiley-VCH.