Table 4.
SMV-specific serum IgA response to SMV challenge in pre- and post- samples
| Infection Statusa | |||
|---|---|---|---|
| Infected (n = 25) | Uninfected (n = 8) | P valueb | |
| Day 1c | |||
| N | 25 | 8 | |
| GMT (95% CI) | 8.1 (4.9, 13.4) | 13.8 (2.6, 70.5) | 0.223 |
| GMFR (95% CI) | 0 | 0 | |
| Day 6 | |||
| N | 25 | 6 | |
| GMT (95% CI) | 12.4 (6.1, 25.2) | 34.1 (12.8, 76.5) | 0.165 |
| GMFR (95% CI) | 1.5 (0.8, 2.9) | 1.3 (0.7, 1.6) | 0.116 |
| Day 15 | |||
| N | 25 | 6 | |
| GMT (95% CI) | 54.2 (25.2, 116.7) | 26.8 (10.1, 59.9) | 0.062 |
| GMFR (95% CI) | 6.7 (2.7, 16.5) | 1.9 (0.4, 1.4) | 0.025 |
| Day 30 | |||
| N | 25 | 5 | |
| GMT (95% CI) | 39.9 (18.4, 86.3) | 25.5 (8.9, 69.9) | 0.231 |
| GMFR (95% CI) | 4.9 (2.0, 11.9) | 1.0 (0.7, 1.3) | 0.012 |
| Day 45 | |||
| N | 22 | 5 | |
| GMT (95% CI) | 50.4 (34.4, 73.8) | 23.4 (7.9, 68.5) | 0.043 |
| GMFR (95% CI) | 5.5 (3.3, 9.2) | 0.9 (0.5, 1.4) | 0.012 |
a
Infection defined as SMV excretion in stool detected through RT-qPCR at any time after challenge through Day 45
b
P value obtained from Kruskal-Wallis test
c
Day 1 denotes pre-challenge
Abbreviation: CI – confidence interval, GMT – geometric mean antibody titers, GMFR – geometric mean fold rise