Table 1.

Practical application of hyperbaric oxygen.

Author	Oxygen concentration	barometric pressure	HBO exposure time per day/minutes	Days	Function	Reference
T Alagoz	100%	2.4atm	90 (30 minutes HBO+10 minutes air+30 minutes HBO+10 minutes air+30 minutes HBO)	5 days in a row	Promote tumor angiogenesis	(71)
Ingrid Moen	100%	2.5bar	90	Day 1, 4, 7	Down-regulate the MAPK pathway and reduce the density of vascular	(74)
Yasuomi Kawasoe	100%	2.5atm	60	5 times a week for 5 weeks	Enhance the effect of chemotherapy	(106)
Xin Liu	100%	2.5atm	90	Day 1, 3, 5	Enhance the immune response of PD-1 antibody to tumor	(31)
Xian Wu	>97%	2.5ata	120	3 days in a row	Relieve tumor hypoxia	(22)
Pan Wang	100%	2.5atm	90	15 days in a row	Inhibit the expression of HIF1 α and HIF2 α	(66)
Xiaoxian Wang	100%	2.5ata	90	Day 1, 2, 3, 4, 7, 10	Inhibit Cancer-Associated Fibroblasts	(64)
Shao-Yuan Chen	98%	2.5ata	90	14 days in a row	Improve tumor angiogenesis	(54)
Linda Elin Birkhaug Stuhr	>97%	2bar	90	Day 1, 4, 7	Induce apoptosis of tumor cells	(75)
Yong-Gang Wang	100%	2.5atm	60	10 days in a row	Inhibit T cell maturation	(90)
Chunxia Chen	100%	2.46atm	60	Day 1	Reduce ROS in cells and lipids and inhibit iron death	(107)
Qin Hu	–	2.5ata	90	One cycle is 7 consecutive days, with a rest of 5 days. Three cycles	Promote neural function recovery through ROS/HIF-1 α/β-catenin pathway	(108)

atm, atmospheres; ata, atmospheres absolute; MAPK, Mitogen-activated protein kinase.