Figure 6.
Iron-related parameters in Hbbth3/+ mice afer vamifeport treatment alone or in combination with repeated blood transfusions. Representative scatter plots of individual values (with mean and standard deviation) showing the effects of transfusion, vehicle, and vamifeport treatment at the end of the study on: (A) serum iron, (B) transferrin, (C) transferrin saturation, (D) erythropoietin, (E) Hamp1 mRNA, (F) serum hepcidin. WT: wild-type. Analysis was performed by using one-way analysis of variance with Dunnett’s multiple comparison test. Significant differences compared with the Hbbth3/+ vehicle nontransfused group (black) and vehicle-transfused group (purple) are indicated as: *P<0.05, **P<0.01, and ***P<0.001.