Table 3.

Secondary outcomes

Outcome	Spironolactone (%)	Placebo (%)	Unadjusted odds ratio (95% CI)	Adjusted* odds ratio (95% CI)
Self-assessed overall improvement score of 3-6:
12 weeks	122/169 (72)	108/159 (68)	1.23 (0.76 to 1.96)	1.16 (0.70 to 1.91)
24 weeks	131/160 (82)	81/128 (63)	2.62 (1.53 to 4.50)	2.72 (1.50 to 4.93)†
Satisfaction with trial treatment, score 3-5:
24 weeks	101/143 (71)	53/123 (43)	3.18 (1.91 to 5.27)	3.12 (1.80 to 5.41)†
PGA success score:
12 weeks	36/176 (21)	20/166 (12)	1.91 (1.05 to 3.45)	1.69 (0.89 to 3.19)
24 weeks	53/164 (32)	15/136 (11)	3.93 (2.09 to 7.37)	3.76 (1.95 to 7.28)†
IGA success score:
12 weeks	31/168 (19)	9/160 (6)	3.78 (1.73 to 8.27)	5.18 (2.18 to 12.28)†

Data are number of participants/total number (percentage), unless otherwise specified. CI=confidence interval; IGA=investigator’s global assessment; PGA=participant’s global assessment; QoL=quality of life.

^*Adjusted for stratification factors (site and baseline severity (IGA <3 versus 3 or more)), baseline Acne-QoL symptom subscale score, topical treatment use (yes/no to using any topical treatment), hormonal treatment, age, and polycystic ovary syndrome status.

^†Statistically significant differences indicated.