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. 2023 Jun 8;33(10):762–774. doi: 10.1038/s41422-023-00830-2

Fig. 5. Schematic diagrams summarizing the conformational changes of the mGlu heterodimers during activation.

Fig. 5

Helices IV and VI in the TMDs are highlighted by colors of blue and brown, respectively. The PAMs that modulate the heterodimer activity in inter- and intra-subunit manners are colored red and green, respectively.