Table 4.

Evaluation of associations of CRS duration quartiles (for each of two definitions of CRS) with new onset asthma from fully adjusted^* final models.

CRS duration variable	HR (95% CI)
CRS positive CT scan, duration from sinus CT to risk set year
No (reference)	1.0
0.10 to 1.72 years	2.75 (2.20, 3.43)
1.73 to 3.74 years	2.20 (1.69, 2.86)
3.75 to 6.38 years	2.37 (1.81, 3.10)
6.39 to 13.99 years	1.27 (0.84, 1.91)
CRS prevalence, two diagnoses, duration from first diagnosis to risk set year
No (reference)	1.0
0.10 to 2.23 years	2.17 (1.96, 2.40)
2.24 to 4.61 years	1.40 (1.22, 1.59)
4.62 to 7.57 years	1.20 (1.03, 1.40)
7.58 to 13.99 years	0.82 (0.67, 1.01)

Abbreviations: COPD = chronic obstructive pulmonary disease; CRS = chronic rhinosinusitis; CT = computed tomography; GERD = gastroesophageal reflux disease; OSA = obstructive sleep apnea

^*All models adjusted for age (linear, squared, and cubic terms); sex (female vs. male); cumulative outpatient encounters through calendar year (0, 1 to < 3, 3 to < 6, 6 to < 11 [reference], 11 to < 18, 18 to < 30, 30+); Medical Assistance (% time using > 0% vs. none); tobacco use (current, former, unknown vs. never); body mass index (kg/m², BMI, BMI²), year (indicator for every year 2009 to 2018 vs. 2013 [reference]); race (Non-White vs. White); ethnicity (Hispanic vs. non-Hispanic); COPD, allergic rhinitis, GERD, and OSA (ever vs. never based on two diagnoses); pneumonia (ever vs. never based on one diagnosis); and history of blood eosinophilia > 500 cells/μL (ever vs. never). All covariates were assessed through the end of the risk set year.