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. 2023 Oct 2;13(4):e12293. doi: 10.1002/pul2.12293

Figure 2.

Figure 2

Effect of macitentan, selexipag, and tadalafil on BMPRII noncanonical signaling pathway in HLMVECs. Representative Western blots of phosphorylated (P‐p38 MAPK) and total p38MAPK in control (a) and bmpr2‐silenced HLMVECs (b) incubated with vehicle (VEH), macitentan (MACI), selexipag (SELEX) and tadalafil (TADA) for 1 h. Quantitative expression of phosphorylated versus total p38MAPK in control (c) and bmpr2‐silenced HLMVECs (d) in bmpr2‐silenced HLMVECs. Results are presented as ratio of phosphorylated over total p38 MAPK protein expression. Independent experiments were performed in four replicates for HLMVECs between passages 5 and 8 and expressed as median (25th–75th interquartile range). Comparisons by one‐way ANOVA and post‐hoc Tukey's multiple tests (c, d).