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[Preprint]. 2023 Sep 18:rs.3.rs-3294233. [Version 1] doi: 10.21203/rs.3.rs-3294233/v1

Figure 7: Foxj1a is required for MGPC proliferation.

Figure 7:

(A). UMAPs showing the gene expression pattern of foxj1a between injury (left) and development model (right).

(B). UMAPs showing the chromVAR motif activity of foxj1a between injury (left) and development model (right).

(C) Tg(gfap:GFP) retinas electroporated with either Standard Control morpholino (Cont MO), pcna MO, or foxj1a MO were isolated 72 hours after NMDA injection and immunostained for PCNA, GFP, and counterstained with DAPI. (D) Quantification of the number of PCNA-labeled cells in the INL. (E) Quantification of the number of PCNA-labeled cells in the ONL. (F) Tg(gfap:GFP) retinas electroporated with either Cont MO, pcnaMO, or foxj1a MO were isolated 72 hours after starting constant light and immunostained for PCNA, GFP, and DAPI. (G) Quantification of the number of PCNA-labeled cells in the INL. (H) Quantification of the number of PCNA-labeled cells in the ONL. Scale bars in A and D are 20μm.