Table 1.
Timetable for rats in the nicotine self-administration study.
| Pre-session Injection (For all THC Groups) | Experimental Session | Post-session Injection (Daily Throughout the Study) | Duration of this Phase |
|---|---|---|---|
| None | None | According to group assignment (0, 3, or 30 mg/kg THC) | 14 Days |
| None | Autoshaping (sucrose reinforcement) | According to group assignment | 3 Days |
| None | Acquisition of self-administration (FR1–5; 30 μg/kg/inf nicotine) | According to group assignment | 30 Days |
| None | FR5; 1.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| None | FR5; 7.5 μg/kg/inf nicotine | According to group assignment | 3 Days |
| None | FR5; 15.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| None | FR5; 30.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| None | FR5; Saline | According to group assignment | 5 Days |
| THC Vehicle on Day 6 | FR5; 30.0 μg/kg/inf nicotine | According to group assignment | 6 Days |
| 0.3 mg/kg THC on Day 3 | FR5; 1.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 0.3 mg/kg THC on Day 3 | FR5; 7.5 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 0.3 mg/kg THC on Day 3 | FR5; 15.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 0.3 mg/kg THC on Day 3 | FR5; 30.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 0.3 mg/kg THC on Day 5 | FR5; Saline | According to group assignment | 5 Days |
| THC Vehicle on Day 6 | FR5; 30.0 μg/kg/inf nicotine | According to group assignment | 6 Days |
| 3.0 mg/kg THC on Day 3 | FR5; 1.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 3.0 mg/kg THC on Day 3 | FR5; 7.5 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 3.0 mg/kg THC on Day 3 | FR5; 15.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 3.0 mg/kg THC on Day 3 | FR5; 30.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 3.0 mg/kg THC on Day 5 | FR5; Saline | According to group assignment | 5 Days |
| THC Vehicle on Day 6 | FR5; 30.0 μg/kg/inf nicotine | According to group assignment | 6 Days |
| 30.0 mg/kg THC on Day 3 | FR5; 1.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 30.0 mg/kg THC on Day 3 | FR5; 7.5 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 30.0 mg/kg THC on Day 3 | FR5; 15.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 30.0 mg/kg THC on Day 3 | FR5; 30.0 μg/kg/inf nicotine | According to group assignment | 3 Days |
| 30.0 mg/kg THC on Day 5 | FR5; Saline | According to group assignment | 5 Days |