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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: J Am Med Dir Assoc. 2023 Jun 15;24(10):1465–1470.e1. doi: 10.1016/j.jamda.2023.05.011

Table 2.

Estimates from multilevel modeling of change in personality in relation to cognitive impairment.

Neuroticism Extraversion Openness Agreeableness Conscientiousness
b SE p b SE p b SE p b SE p b SE p
Intercept 0.313 0.036 <.001 −0.514 0.037 <.001 −1.042 0.035 <.001 −1.035 0.035 <.001 −0.991 0.036 <.001
Age −0.148 0.008 <.001 0.051 0.008 <.001 −0.023 0.008 0.005 0.038 0.008 <.001 −0.026 0.008 0.002
Age2 0.023 0.005 <.001 −0.050 0.005 <.001 −0.031 0.005 <.001 −0.031 0.005 <.001 −0.027 0.005 <.001
Gender (Women) 0.187 0.012 <.001 0.162 0.013 <.001 0.011 0.012 0.365 0.514 0.012 <.001 0.217 0.012 <.001
Education −0.037 0.002 <.001 0.023 0.002 <.001 0.085 0.002 <.001 0.022 0.002 <.001 0.054 0.002 <.001
Black −0.279 0.016 <.001 0.136 0.017 <.001 0.106 0.016 <.001 −0.004 0.016 0.796 −0.101 0.016 <.001
Other race −0.069 0.025 0.005 0.009 0.025 0.714 0.030 0.024 0.219 −0.054 0.024 0.026 −0.040 0.025 0.104
Latinx 0.061 0.022 0.005 0.011 0.022 0.616 −0.014 0.021 0.513 −0.078 0.021 <.001 0.040 0.021 0.064
Time −0.178 0.023 <.001 −0.144 0.022 <.001 −0.184 0.022 <.001 −0.111 0.023 <.001 0.016 0.023 0.478
Time2 0.054 0.022 0.014 0.065 0.021 0.002 0.139 0.021 <.001 0.048 0.022 0.032 0.024 0.022 0.281
Age*Time 0.055 0.013 <.001 −0.011 0.013 0.399 −0.037 0.013 0.004 −0.010 0.013 0.449 −0.068 0.014 <.001
Before-CI 0.044 0.024 0.074 −0.098 0.023 <.001 −0.058 0.023 0.011 −0.111 0.024 <.001 −0.118 0.024 <.001
During-CI 0.101 0.030 0.001 −0.143 0.029 <.001 −0.147 0.028 <.001 −0.353 0.031 <.001 −0.344 0.031 <.001

Note. CI= cognitive impairment. Age and time (including before and during cognitive impairment) are in decades. Fully unconditional models, with no predictors, were used to estimate within-person variance of the traits, which ranged from 30% for extraversion to 37% for agreeableness. Follow-up analyses found that within-person variance was generally larger in the subsample cognitively impaired at any point in the study (e.g., for neuroticism: 33% for the cognitively unimpaired and 47% in those cognitively impaired; for conscientiousness: 31% for the cognitively unimpaired and 57% in those cognitively impaired). Nominal p-value reported and considered significant if p < .01. Results also hold if accounting for multiple testing using Benjamini and Hochberg’s false discovery rate method.