Figure 2. Three major compartments where ICAM-1 influences immune cell activity.
Three possiblities for ICAM-1 to influence autoimmunity include: 1) priming of T-cells (left panel), 2) trafficking of immune cells (middle panel), and 3) effector function (right panel). While ICAM-1 likely performs these roles as part of healthy immune cell activity, each of these processes may contribute to ICAM-1 dependent events that lead to islet beta-cell loss during autoimmunity and islet graft rejection. This figure was generated using BioRender.