Figure 1. TLR7 is expressed in B cells, DCs, and myeloid cells and is deleted in targeted subsets using Cre-lox approaches.

(A and B) Representative histograms and quantification in the change in anti-TLR7 PE MFI between WT and Tlr7^–/y for each of the defined populations in 6-week-old male, prediseased MRL/lpr mice. (C) Representative histograms showing TLR7 expression in a littermate control (Tlr7^fl/y) mouse (blue line), a CD11c-Tlr7^Δ (CD11c-Cre^+/– Tlr7^fl/y) mouse (red line), and a Tlr7^–/y mouse (black dotted line) in relevant cell subsets. (D) Representative histograms showing TLR7 expression in a littermate control (Tlr7^fl/y) (blue line), a B-Tlr7^Δ (CD19-Cre^+/– Tlr7^fl/y) mouse (red line), and a Tlr7^–/y mouse (black dotted line) in relevant cell subsets.