Table 3.

Chronic health conditions in association with the presence of PhenoAgeAccel*

Chronic health conditions	Odds ratio (95%CI)	p value
Cardiovascular disease	1.899 (1.445–2.497)	0.001
Respiratory disease	1.284 (0.891–1.850)	0.180
End-stage renal failure	28.9 (12.686–65.838)	0.001
Cirrhosis	2.749 (1.623–4.656)	0.001
Immune disease	1.807 (1.103–2.960)	0.019
Immunosuppressed	1.826 (1.397–2.388)	0.001
AIDS	0.876 (0.146–5.248)	0.884
Lymphoma	1.104 (0.652–1.869)	0.713
Metastatic cancer	0.827 (0.598–1.145)	0.253
Leukemia	1.482 (0.860–2.554)	0.157
Diabetes mellitus	3.128 (2.316–4.224)	0.001

All comorbidities except diabetes mellitus are defined according to the Acute Physiology and Chronic Health Evaluation (APACHE) II model. *PhenoAgeAccel is a dichotomized estimate to reflect whether the biological age of the patient is older than the chronological age while accounting for the PhenoAge of the whole cohort by regressing PhenoAge on chronological age; a positive residual means a patient’s phenotypical or biological age is older than their chronological age compared to other patients included in this study. CI, confidence interval