Fig. 5.

Ripk2 deficiency protects male and female mice from stroke injury 48 h after permanent MCAO. A TTC staining of brains of aged (18–24 months) male Ripk2^+/+ and Ripk2^−/− mice 48 h after stroke. B Quantification of infarct size from TTC staining in A. C Infarct size quantified for each coronal section. D TTC staining of aged female Ripk2^+/+ and Ripk2.^−/− mice 48 h after stroke. E Quantification of infarct size from TTC staining in D. F Infarct size quantified for each coronal section. A–C n = 5–6/genotype. D–F n = 3–5/genotype. Student’s t test. *P < 0.05, **P < 0.01, ****P < 0.0001