Fig. 9.

Microglial deletion of Ripk2 improves acute behavioral outcomes after stroke. A–D Locomotor function was assessed by the open field test. Graphical depictions of track plots and corresponding heatmaps (A) reveal greater distances traveled by Ripk2 conditional knockout mice (μKO) compared to wild type (WT) at 24 h and 48 h after stroke (B), with clear separation between groups when examining each minute of the open field test (C, D). E Weight grip scores. F Time required to descend the vertical grid. G–J Neurological deficits scores (NDS). Total score at 24 h (G) with scores of individual parameters in H. Total score at 48 h (I) with individual scores in J. A–J n = 14–15/group. A–E Two-way ANOVA (G–J) Mann–Whitney test. *P < 0.05, **P < 0.01, ***P < 0.001 ****P < 0.0001