TABLE 2.
Pharmacokinetic parameters of amoxicillin and cefotaxime (alone and in combination) in uninfected rabbits after a single i.m. injectiona
| Regimen (mg/kg) | Concn in plasma (μg/ml)
|
t1/2βb (min) | AUC0–∞c (min · mg/liter) | Vβd (liters/kg) | |
|---|---|---|---|---|---|
| Peak (Cmax)e | Trough | ||||
| Amoxicillin (50) | 28 ± 10 | 0.8 ± 0.5 | 70 ± 20 | 2,500 ± 500 | 2.1 ± 0.7 |
| Amoxicillin (50) + cefotaximef (50) | 29 ± 9 | 0.4 ± 0.4 | 80 ± 33 | 2,100 ± 400 | 2.7 ± 1.0 |
| Amoxicillin (150) | 68 ± 32 | 5.5 ± 2.9 | 130 ± 38 | 9,500 ± 3,200 | 4.1 ± 2.3 |
| Cefotaxime (50) | 56 ± 26 | 0.9 ± 1.3 | 45 ± 14 | 4,600 ± 800 | 0.7 ± 0.2 |
| Cefotaxime (50) + amoxicillinf (50) | 56 ± 22 | 1.4 ± 0.7 | 74 ± 33 | 5,200 ± 1,700 | 1.2 ± 0.8 |
| Cefotaxime (150) | 102 ± 19 | 6.9 ± 4.0 | 158 ± 57 | 13,800 ± 2,900 | 2.6 ± 1.0 |
| Gentamicin (1) | 2.1 ± 1 | <0.27 | 61 ± 14 | 311 ± 103 | 0.4 ± 0.2 |
a
Each value is the mean (± standard deviation) of measurements made for at least six animals.
b
t1/2, half-life.
c
AUC, area under the concentration-time curve.
d
V, volume of distribution.
e
Cmax, maximum concentration of drug in serum.
f
The drug indicated was coadministered, but its pharmacokinetic parameters were not determined.