Table 2.
Summary of some approved combined and single drug-based chemotherapy regimens.
| Chemotherapy regimen | Injection program | Type | Components | Ref. |
|---|---|---|---|---|
| Lokich | Daily IV injection | Single | 5-FU (300 mg/m2) | (111) |
| TTD | IV infusion daily for 5 days, repeated every 28 days | Combined | 1. Bolus leucovorin (200 mg/m2) 2. 5-FU (370 mg/m2) | (112) |
| FOLFOX-4 | Programed infusion in 2 day | Combined | 1. Leucovorin (200 mg/m2, day 1,2) 2. 5-FU bolus (400 mg/m2, day 1,2) 3. Continuous infusion 5-FU (600 mg/m2 for 22 h, day 1,2) 4. Oxaliplatin (85 mg/m2 day 1) |
(113) |
| FOLFOX-6 | Programed infusion in 2 day | Combined | 1. Leucovorin (400 mg/m2 IV, day 1) 2. 5-FU (400 mg/m2 IV bolus on day 1; then a continuous infusion of 1,200–1,500 mg/m2/day × 2 days) 3. Oxaliplatin (100 mg/m2 IV, day 1) |
(113) |
| FOLFIRI | Programed infusion in 2 day | Combined | 1. Leucovorin (400 mg/m2 IV, day 1) 2. 5-FU (400 mg/m2 IV bolus, day 1; then a continuous infusion of 1,200–1,500 mg/m2/day × 2 days) 3. Irinotecan (180 mg/m2 IV, day 1) |
(114) |
| FOLFOXIRI | Programed infusion in 2 day | Combined | 1. Irinotecan (165 mg/m2 over 60 min) 2. Oxaliplatin (85 mg/m2) 3. Leucovorin (200 mg/m2 over 120 min) 4. 5-FU (3200 mg/m2 continuous infusion for 48 h) |
(115) |
| Capecitabine | Twice daily, days 1–14 | Single | Capecitabine (1000–1250 mg/m2) | (116) |
| CAPOX/XELOX | Twice daily, days 1–14 | Combined | 1. Capecitabine (1,000 mg/m2 twice daily PO for 14 days) 2. Oxaliplatin (130 mg/m2 IV, day 1) |
(117) |
| mXELIRI | Daily, days 1–14 | Combined | 2. Irinotecan 200 mg/m2 (Day1) 1. Capecitabine 1,600 mg/m2/day (Day 1–14), |
(118) |